Clinical Significance
Mutations in OTX2 can cause eye disorders including anophthalmia and microphthalmia.
It has been shown that if Otx2 is over expressed it can lead to childhood malignant brain tumors called medulloblastomas.
Read more about this topic: Orthodenticle Homeobox 2
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)