Orthodenticle Homeobox 2

Orthodenticle Homeobox 2

Identifiers Symbols OTX2; CPHD6; MCOPS5 External IDs OMIM: 600037 MGI: 97451 HomoloGene: 11026 GeneCards: OTX2 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • sequence-specific DNA binding transcription factor activity • protein binding • eukaryotic initiation factor 4E binding • sequence-specific DNA binding • protein heterodimerization activity
Cellular component	• nucleus • cytoplasm • growth cone • protein complex
Biological process	• cell fate specification • regulation of transcription, DNA-dependent • protein complex assembly • axon guidance • endoderm development • regulation of smoothened signaling pathway • dorsal/ventral pattern formation • metencephalon development • forebrain development • midbrain development • somite rostral/caudal axis specification • positive regulation of embryonic development • regulation of fibroblast growth factor receptor signaling pathway • inner ear morphogenesis • eye photoreceptor cell fate commitment • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • diencephalon morphogenesis • primitive streak formation • positive regulation of gastrulation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5015 18424 Ensembl ENSG00000165588 ENSMUSG00000021848 UniProt P32243 P80206 RefSeq (mRNA) NM_001270523 NM_144841 RefSeq (protein) NP_001257452 NP_659090 Location (UCSC) Chr 14:
57.27 – 57.28 Mb Chr 14:
48.66 – 48.67 Mb PubMed search

Homeobox protein OTX2 is a protein that in humans is encoded by the OTX2 gene.