Pathology
It can be the source of paraganglioma or pheochromocytoma.
The organ of Zuckerkandl is of pathological significance in the adult as a common extra-adrenal site of pheochromocytoma though the most common extra-adrenal site is in the superior para-aortic region between the diaphragm and lower renal poles.
Extra-adrenal tumors account for around 10% of all cases of pheochromocytoma. Resection has been described.
In addition to its endocrine effects, it can also cause obstructive pathology.
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