Orangeburg may refer to:
- Orangeburg, New York
- Orangeburg, South Carolina
- Orangeburg County, South Carolina
- Orangeburg Dodgers, a minor league baseball team
- Orangeburg Municipal Airport, a public airport
- Orangeburg Railway, a shortline railroad
- Orangeburg pipe, a type of pipe made from tar paper
- Orangeburg massacre, an incident on February 8, 1968