- Jason Belmonte, professional tenpin bowler, born in Orange in 1983
- Billy Bevan (1887–1957), actor, born in Orange
- Kate Bracks, winner of the third series of MasterChef Australia, from Orange
- Darren Britt, former professional rugby league player, born in Orange in 1969
- Murray Cook, a vocalist, songwriter and guitarist; best known as one of the members of The Wiggles, grew up in Orange
- Sir Charles Cutler (1918–2006), a former politician including holding office for 28 years as an elected Member for Orange, and former Deputy Premier
- James Dalton (1834–1919), an early Australian merchant, pastoralist, and Roman Catholic lay leader, a key figure in the early development of Orange and district
- J. J. Dalton (1861–????), the second son of James Dalton, the first Australian born member of the British Parliament, born in Orange
- Mark Furze, a television actor and singer, born in Orange in 1986
- Tim Gartrell, former National Secretary of the Australian Labor Party and now Chief Exeuctive of GenerationOne, born in Orange in 1970
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- Frederick Hanson (1914–1980), former Commissioner of New South Wales Police, born in Orange
- Sir Neville Howse, VC (1863–1930), the first Australian recipient of the Victoria Cross, a physician living in Orange, twice elected Mayor, and later federal politician
- David Lyons, professional rugby union player, born in Orange in 1980
- James Maloney, professional rugby league player, born in Orange in 1986
- Daniel Mortimer, professional rugby league player, born in Orange in 1989
- Peter Mortimer, father of Daniel Mortimer, a former rugby league player and manager, now news reporter and winery owner, living in the Orange region
- Lucas Parsons, professional golfer, born in Orange in 1969
- Banjo Paterson (1864–1941), poet, born near Orange
- Kenneth Slessor (1901–1971), poet, born in Orange
- Susan, Crown Princess of Albania (1941–2004), the wife of Leka, Crown Prince of Albania, educated and taught art at Presbyterian Ladies College, Orange
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