Opioid Comparison - Morphine-centric Chart

Morphine-centric Chart

Opioids are a class of compounds that elicit analgesic (pain killing) effects in humans and animals by binding to the μ-opioid receptor within the central nervous system. The following table lists commonly used opioid drugs and their relative potencies. Values for the potencies of opioids listed on this table are given as taken orally unless another route of administration is provided. As such, their bioavailabilities differ, and they may be more potent when taken intravenously. Methadone is different from most opioids considering its potency can vary depending on how long it is taken. Acute use; 1–3 days, yields a potency about 4× stronger than that of morphine and chronic use (7 days+) yields a potency about 7–8× that of morphine due to methadone being stored in fat tissue, thus giving higher serum levels with longer use.

Equianalgesia
(morphine)
Analgesic Strength
 Equivalent dose
 Bioavailability Half-life of active metabolites
Aspirin (non-opioid) 1/360 no equivalent dose total 3.1–9
Diflunisal (NSAID, non-opioid) 1/160 1600 mg 80–90% 8–12
Acetaminophen IV (non-opioid) 1/25 250 mg 100%
Dextropropoxyphene 1/13 to 1/20 130–200 mg
Codeine 1/10 100 mg ≈90% 2.5–3 (C6G 1.94; morphine 2–3)
Tramadol 1/10 100 mg 68–72% 5.5–7 (≈9)
Dihydrocodeine 1/5 50 mg 20% 4
Tapentadol 1/10 100 mg 95%
Anileridine 1/4 40 mg
Alphaprodine 1/4–1/6 40–60 mg
Pethidine (meperidine hydrochloride) 1/3 28 mg 50–60% 3–5
Hydrocodone 1 10 mg ≥80% 3.8–6
Metopon 1 10 mg
Pentazocine lactate (IV) 1 10 mg (6.7–13.3 mg)
Morphine (oral) (1) (10 mg) ≈25%
Oxycodone 1.5–2.0 5.0–6.7 mg ≤87% 3–4.5
Morphine (IV/IM) 3 3.33 mg 100% 2–3 mg
Clonitazene 3 3.33 mg
Methadone (acute) 3–4 2.5–3.33 mg 40–90% 15–60
Diamorphine (Heroin; IV/IM) 4–5 2–2.5 mg 100% <0.6
Hydromorphone 5 2 mg 30–35% 2–3
Oxymorphone 7 1.4 mg 10% 7.25–9.43
Methadone (chronic) 7.5 1.35 mg 40–90% 15–60
Levorphanol 8 1.3 mg 70% 11–16
7-Hydroxymitragynine 17 ≈.6 mg
Buprenorphine 40 0.25 mg 35–40% (sublingual) 20–70, mean 37
Fentanyl 50–100 0.1–0.2 mg 33% (oral); 92% (transdermal) 0.04 (IV); 7 (transdermal)
Sufentanil 500–1,000 10–20 μg 4.4
Bromadol 504 ≈ 20 µg
Etorphine 1000–3000 3.3–10 μg
Etonitazene 2,000 5.0 µg
Dihydroetorphine 1000–12,000 20–40 µg
Carfentanil 10,000–100,000 0.1–1.0 μg 7.7

Read more about this topic:  Opioid Comparison

Famous quotes containing the word chart:

    “Perhaps in His wisdom the Almighty is trying to show us that a leader may chart the way, may point out the road to lasting peace, but that many leaders and many peoples must do the building.”
    —Eleanor Roosevelt (1884–1962)