In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“Don: Why are they closed? They’re all closed, every one of them.
Pawnbroker: Sure they are. It’s Yom Kippur.
Don: It’s what?
Pawnbroker: It’s Yom Kippur, a Jewish holiday.
Don: It is? So what about Kelly’s and Gallagher’s?
Pawnbroker: They’re closed, too. We’ve got an agreement. They keep closed on Yom Kippur and we don’t open on St. Patrick’s.”
—Billy Wilder (b. 1906)
“They don’t advertise for killers in the newspaper. That was my profession. Ex-cop. Ex- blade runner. Ex-killer.”
—David Webb Peoples, U.S. screenwriter, and Ridley Scott. Rick Deckard, Blade Runner, reading the newspaper—his opening lines (1982)
“Candor is a proof of both a just frame of mind, and of a good tone of breeding. It is a quality that belongs equally to the honest man and to the gentleman.”
—James Fenimore Cooper (1789–1851)