Olivopontocerebellar atrophy (OPCA) is a term that describes the degeneration of neurons in specific areas of the brain – the cerebellum, pons, and inferior olives. OPCA is present in several neurodegenerative syndromes, including inherited and non-inherited forms of ataxia (such as the hereditary spinocerebellar ataxia known as Machado–Joseph disease) and multiple system atrophy (MSA), with which it is primarily associated.
OPCA may also be found in the brains of individuals with prion disorders and inherited metabolic diseases. The characteristic areas of brain damage that indicate OPCA can be seen by imaging the brain using CT scans or MRI studies.
The use of the term has changed considerably in recent years due to the progressing knowledge of the genetic basis of the disease.
The term was originally coined by Joseph Jules Dejerine and André Thomas.
Read more about Olivopontocerebellar Atrophy: Signs and Symptoms, Cause, Obsolete Uses of The Term, Physiotherapy Intervention
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