Adverse Effects
As with all neuroleptic drugs, olanzapine can cause the (sometimes) irreversible movement disorder tardive dyskinesia, and the rare, but life-threatening, neuroleptic malignant syndrome. Some also associate all antipsychotics with permanent brain damage.
Other recognised side effects may include:
- akathisia; inability to remain still (restlessness)
- anhedonia (may result from the breakdown in the brain's reward system, involving the neurotransmitter dopamine)
- dry mouth
- red eye
- mydriasis
- dizziness
- irritability
- sedation
- insomnia
- constipation
- urinary retention
- orthostatic hypotension
- heart failure, heart attack, or stroke;
- weight gain
- increased appetite
- runny nose
- impaired judgment, thinking, and motor skills
- impaired spatial orientation
- impaired responses to senses
- seizures
- trouble swallowing
- dental problems and discoloration of teeth
- missed periods
- problems with keeping body temperature regulated
- apathy, lack of emotion
- Endocrine side effects have included hyperprolactinemia, hyperglycemia, and diabetes mellitus
- Brain Zaps (may result from the blockade of serotonin receptors, since SSRI discontinuation can cause brain zaps and vertigo too)
- Auditory Hallucinations
Read more about this topic: Olanzapine
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