OGC may refer to:
- Oculogyric crisis, a dystonic reaction to certain drugs and/or medical conditions
- Office of Government Commerce, a department of the government of the United Kingdom
- Office of the General Counsel, in many corporations and public institutions
- Open Geospatial Consortium, a standards organization for geospatial information systems
- Orchestral Game Music Concerts, a series concerts of video game music performed in Tokyo, Japan
- Organically Grown Company, an organic produce wholesale company
- Originoo Gunn Clappaz, a hip hop group from Brooklyn, New York
- Outwood Grange College, a large British secondary school and sixth form in Wakefield, West Yorkshire
- Giuseppe Conzo's Observatory, an astronomical place to observe the sky
- ASCII Art representation of male masturbation.