OFA or Ofa may refer to:
- Occipital Face Area
- Ontario Federation of Agriculture, a farmer lobbying organization
- Orthopedic Foundation for Animals, a non-profit organization for researching diseases of animals
- Optical Fiber Amplifier
- Optimal Flexible Architecture, a standard for naming files and folders in an Oracle database
- Old Faujians Association, an ex-cadet association for the Cadet College in Bangladesh
- Ogdensburg Free Academy, a middle/high school in northern New York
- Omilos Filon Astronomias, a group of amateur astronomers in Thessaloniki, Greece
- Oracle Fusion Applications, Oracle product
- Oracle Fusion Architecture, Oracle standard
- Oracle Financial Analyzer, Oracle software
- Organizing for America, an American political group affiliated with the Democratic Party
- Obama for America, the general election campaign which elected Barack Obama the 44th President of the United States in 2008
- Ufa, Bashkortostan, Russia