Oesophagostomum - Management and Therapy

Management and Therapy

The typical adult therapy for oesophagostomiasis is a single 400 mg dose of albendazole (200 mg for children) or pyrantel pamoate. Albendazole works by binding to the free beta tubulin, which inhibits tubulin polymerization. This results in the inhibition of glucose uptake by the Oesophagostomum. Albendazole and pyrantel pamoate at these doses have cure rates of 85% and 59-82%, respectively. Excision of Oesophagostomum larvae from nodules has been shown to have a curative effect on the patient but is invasive and more resource intensive than chemotherapy.

For oesophagostomiasis with complications, the type of treatment varies depending on the severity of the disease. Usually 200–400 mg of albendazole will be given immediately and continued for up to 5 days in conjunction with 250 mg dosages of amoxicillin. In the case of formation of abscesses or fistulae arising from Dapaong tumors, incision and drainage is performed, followed by a regimen of albendazole and antibiotic treatment.