Mechanism of Action
Omeprazole is a selective and irreversible proton pump inhibitor. Omeprazole suppresses gastric acid secretion by specific inhibition of the hydrogen–potassium adenosinetriphosphatase (H +, K +-ATPase) enzyme system found at the secretory surface of parietal cells. It inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen. Since the H +, K +-ATPase enzyme system is regarded as the acid (proton) pump of the gastric mucosa, omeprazole is known as a gastric acid pump inhibitor. The inhibitory effect is dose-related. Omeprazole inhibits both basal and stimulated acid secretion irrespective of the stimulus.
Read more about this topic: Ocid
Famous quotes containing the words mechanism of, mechanism and/or action:
“Life is an offensive, directed against the repetitious mechanism of the Universe.”
—Alfred North Whitehead (1861–1947)
“The law isn’t justice. It’s a very imperfect mechanism. If you press exactly the right buttons and are also lucky, justice may show up in the answer. A mechanism is all the law was ever intended to be.”
—Raymond Chandler (1888–1959)
“The bugle-call to arms again sounded in my war-trained ear, the bayonets gleamed, the sabres clashed, and the Prussian helmets and the eagles of France stood face to face on the borders of the Rhine.... I remembered our own armies, my own war-stricken country and its dead, its widows and orphans, and it nerved me to action for which the physical strength had long ceased to exist, and on the borrowed force of love and memory, I strove with might and main.”
—Clara Barton (1821–1912)