Obafemi may refer to:
- Abiodun Obafemi (born 1973), Nigerian footballer
- Obafemi Awolowo (1909–1987), Nigerian politician and leader
- Obafemi Awolowo University, a government-owned and operated Nigerian university
- Obafemi Awolowo University massacre, a series of shootings and murders which took place against students in 1999
- Students’ Union of Obafemi Awolowo University governs student affairs at the institution
- Obafemi Awolowo University, a government-owned and operated Nigerian university
- Obafemi Ayanbadejo (born 1975), American football fullback
- Obafemi Martins (born 1984), Nigerian football player