NWO may refer to:
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek, the Dutch Organisation for Scientific Research, a scientific research organisation in the Netherlands
- New World Order (disambiguation)
- New World Order (professional wrestling), former professional wrestling stable in World Championship Wrestling (WCW) and World Wrestling Entertainment (WWE); generally typeset as "nWo" as depicted in the logo of the original stable
- New World Orphans, an album by Hed PE
- New Worlds Observer, proposed orbital telescope system designed for locating planets in other solar systems
- "N.W.O.", 1992 song by the industrial band Ministry
- WWE No Way Out, annual professional wrestling pay-per-view event