Computing
- Nuke (software), a node-based compositor
- Duke Nukem, a series of video games with a protagonist of the same name
- Nuke (gaming), a damaging attack in a role-playing game
- Nuke (warez)
- WinNuke, a Microsoft Windows exploit
- A kind of denial-of-service attack against a computer network
- Nuclear War MUD, a text-based online role-playing game
- Several content management systems, including:
- PHP-Nuke
- PostNuke
- DotNetNuke
- RavenNuke
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