NUDCD3 (gene)

Identifiers Symbols NUDCD3; NudCL External IDs OMIM: 610296 MGI: 2144158 HomoloGene: 9097 GeneCards: NUDCD3 Gene

Gene Ontology
Molecular function	• protein binding
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23386 209586 Ensembl ENSG00000015676 ENSMUSG00000053838 UniProt Q8IVD9 Q8R1N4 RefSeq (mRNA) NM_015332 NM_173748 RefSeq (protein) NP_056147 NP_776109 Location (UCSC) Chr 7:
44.42 – 44.53 Mb Chr 11:
6.11 – 6.2 Mb PubMed search

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.