Nuclear Magnetic Resonance Spectroscopy of Proteins - Automation of The Process

Automation of The Process

Structure determination by NMR has traditionally been a time consuming process, requiring interactive analysis of the data by a highly trained scientist. There has been a considerable interest in automating the process to increase the throughput of structure determination and to make protein NMR accessible to non-experts (See structural genomics). The two most time consuming processes involved are the sequence-specific resonance assignment (backbone and side-chain assignment) and the NOE assignment tasks. Several different computer programs have been published that target individual parts of the overall NMR structure determination process in an automated fashion. Most progress has been achieved for the task of automated NOE assignment. So far, only the FLYA and the UNIO approach were proposed to perform the entire protein NMR structure determination process in an automated manner without any human intervention. Efforts have also been made to standardize the structure calculation protocol to make it quicker and more amenable to automation.

Read more about this topic:  Nuclear Magnetic Resonance Spectroscopy Of Proteins

Famous quotes containing the words automation and/or process:

    Besides black art, there is only automation and mechanization.
    Federico García Lorca (1898–1936)

    The moralist and the revolutionary are constantly undermining one another. Marx exploded a hundred tons of dynamite beneath the moralist position, and we are still living in the echo of that tremendous crash. But already, somewhere or other, the sappers are at work and fresh dynamite is being tamped in place to blow Marx at the moon. Then Marx, or somebody like him, will come back with yet more dynamite, and so the process continues, to an end we cannot foresee.
    George Orwell (1903–1950)