Mixed With Polyketides
Due to the similarity with polyketide synthetases (PKS), many secondary metabolites are, in fact, fusions of NRPs and polyketides. In essence, this occurs when PK modules follow NRP modules, and vice versa. Although there is high degree of similarity between the PCP domains of both types of sythetases, the mechanism of condensation is different from a chemical standpoint (claisen vs. transamidation).
- Epothilone
Read more about this topic: Nonribosomal Peptide
Famous quotes containing the words mixed with and/or mixed:
“Those graceful acts,
Those thousand decencies, that daily flow
From all her words and actions, mixed with love
And sweet compliance, which declare unfeigned
Union of mind, or in us both one soul.”
—John Milton (1608–1674)
“Love sits enthroned in Clara’s eyes,
The Graces play her lips around,
And in her cheeks the tendrest dyes
Of lilly mixed with rose are found.
Where charms so irresistless throng
What mortal heart can try resistance?
But ah! her nose is two feet long,
And bids our passions keep their distance.”
—Horace Walpole (1717–1797)