NME2

NME2

Identifiers Symbols NME2; NDKB; NDPK-B; NDPKB; NM23-H2; NM23B; PUF External IDs OMIM: 156491 MGI: 97356 HomoloGene: 39553 ChEMBL: 2160 GeneCards: NME2 Gene EC number 2.7.13.3, 2.7.4.6

Gene Ontology
Molecular function DNA binding
sequence-specific DNA binding transcription factor activity
nucleoside diphosphate kinase activity
protein histidine kinase activity
protein binding
ATP binding
metal ion binding
Cellular component ruffle
nucleus
cytosol
lamellipodium
Biological process GTP biosynthetic process
UTP biosynthetic process
CTP biosynthetic process
transcription, DNA-dependent
regulation of transcription, DNA-dependent
cell adhesion
nucleoside triphosphate biosynthetic process
nucleobase-containing small molecule interconversion
negative regulation of apoptotic process
small molecule metabolic process
positive regulation of keratinocyte differentiation
regulation of epidermis development
positive regulation of epithelial cell proliferation
nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4831 18103 Ensembl ENSG00000011052 ENSMUSG00000020857 UniProt P22392 Q01768 RefSeq (mRNA) NM_001018137 NM_001077529 RefSeq (protein) NP_001018147 NP_001070997 Location (UCSC) Chr 17:
49.23 – 49.25 Mb Chr 11:
93.95 – 93.96 Mb PubMed search

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.

Read more about NME2:  Interactions