NME2
Gene Ontology | |
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Molecular function | • DNA binding • sequence-specific DNA binding transcription factor activity • nucleoside diphosphate kinase activity • protein histidine kinase activity • protein binding • ATP binding • metal ion binding |
Cellular component | • ruffle • nucleus • cytosol • lamellipodium |
Biological process | • GTP biosynthetic process • UTP biosynthetic process • CTP biosynthetic process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • cell adhesion • nucleoside triphosphate biosynthetic process • nucleobase-containing small molecule interconversion • negative regulation of apoptotic process • small molecule metabolic process • positive regulation of keratinocyte differentiation • regulation of epidermis development • positive regulation of epithelial cell proliferation • nucleobase-containing small molecule metabolic process |
Sources: Amigo / QuickGO |
49.23 – 49.25 Mb
93.95 – 93.96 Mb
Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.
Read more about NME2: Interactions