Nitric Oxide Synthase 2 (inducible)

Nitric Oxide Synthase 2 (inducible)

Identifiers Symbols NOS2; HEP-NOS; INOS; NOS; NOS2A External IDs OMIM: 163730 MGI: 97361 HomoloGene: 55473 ChEMBL: 4481 GeneCards: NOS2 Gene EC number 1.14.13.39

Gene Ontology
Molecular function	• NADPH-hemoprotein reductase activity • nitric-oxide synthase activity • receptor binding • iron ion binding • protein binding • calmodulin binding • FMN binding • heme binding • tetrahydrobiopterin binding • arginine binding • protein homodimerization activity • flavin adenine dinucleotide binding • NADP binding
Cellular component	• intracellular • nucleus • cytoplasm • peroxisome • cytosol • cortical cytoskeleton • perinuclear region of cytoplasm
Biological process	• response to hypoxia • positive regulation of leukocyte mediated cytotoxicity • innate immune response in mucosa • arginine catabolic process • superoxide metabolic process • nitric oxide biosynthetic process • inflammatory response • nitric oxide mediated signal transduction • blood coagulation • response to bacterium • negative regulation of gene expression • peptidyl-cysteine S-nitrosylation • positive regulation of guanylate cyclase activity • regulation of cell proliferation • negative regulation of protein catabolic process • defense response to bacterium • regulation of cellular respiration • negative regulation of blood pressure • positive regulation of vasodilation • regulation of insulin secretion • defense response to Gram-negative bacterium • interaction with host • positive regulation of killing of cells of other organism • cellular response to lipopolysaccharide • cellular response to interferon-gamma • phagosome maturation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4843 18126 Ensembl ENSG00000007171 ENSMUSG00000020826 UniProt P35228 P29477 RefSeq (mRNA) NM_000625 NM_010927 RefSeq (protein) NP_000616 NP_035057 Location (UCSC) Chr 17:
26.08 – 26.13 Mb Chr 11:
78.92 – 78.96 Mb PubMed search

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.