Nickel Chromate - Toxicity

Toxicity

Dermatitis:

Both nickel-containing and chromium-containing compounds are prone to trigger allergic reactions on the skin—often at contact. Given enough exposure, most anyone can react in this way (which is a form of eczema), though those with a nickel or chromium sensitivity are most susceptible.

Carcinogenetic Properties:

Nickel (II) Chromate has been determined to alter H3K4, a common gene activator. Methylation of this compound by NiCrO4 can occur at millimolar and micromolar concentrations, causing mutations in the gene’s tail region. These mutations have been linked to lung cancer and other maladies, making Nickel (II) Chromate an occupational exposure hazard.

Similarly, studies have shown that Nickel (II) Chromate can increase genotoxicity by way of oxidative stress, as well. Malignant tumors and sarcomas have been noted in several studies via injection.