NFE2L2

NFE2L2

Identifiers Symbols NFE2L2; NRF2 External IDs OMIM: 600492 MGI: 108420 HomoloGene: 2412 ChEMBL: 1075094 GeneCards: NFE2L2 Gene

Gene Ontology
Molecular function	• RNA polymerase II activating transcription factor binding • DNA binding • sequence-specific DNA binding transcription factor activity • protein domain specific binding • sequence-specific DNA binding
Cellular component	• chromatin • nucleus • cytoplasm • centrosome • cytosol • plasma membrane
Biological process	• transcription from RNA polymerase II promoter • proteasomal ubiquitin-independent protein catabolic process • protein ubiquitination • positive regulation of blood coagulation • endoplasmic reticulum unfolded protein response • positive regulation of transcription from RNA polymerase II promoter in response to stress • negative regulation of apoptotic process • proteasomal ubiquitin-dependent protein catabolic process • regulation of embryonic development • cellular response to hydrogen peroxide • cellular response to laminar fluid shear stress • regulation of removal of superoxide radicals • positive regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4780 18024 Ensembl ENSG00000116044 ENSMUSG00000015839 UniProt Q16236 Q60795 RefSeq (mRNA) NM_001145412 NM_010902 RefSeq (protein) NP_001138884 NP_035032 Location (UCSC) Chr 2:
178.09 – 178.26 Mb Chr 2:
75.68 – 75.7 Mb PubMed search

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, and dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis