New York State Route 383

New York State Route 383 (NY 383) is an 18.70-mile (30.09 km) north–south state highway in Monroe County, New York, in the United States. The southern terminus of the route is at an intersection with NY 36 in the hamlet of Mumford within the town of Wheatland. Its northern terminus is at a junction with NY 31 in the city of Rochester. The route follows the Genesee River and its tributaries for its entire length and passes through the village of Scottsville.

In the early 20th century, the entirety of modern NY 383 south of Scottsville was part of Route 16, an unsigned legislative route. In 1921, Route 16 was truncated to end in Caledonia while the entirety of its former routing north of the village became part of Route 15. The segment of Route 15 between Mumford and Scottsville became part of NY 253 in the 1930 renumbering of state highways in New York. This section of NY 253 was replaced c. 1938 by a rerouted NY 35, a route that extended northeast of Scottsville to Ontario by way of Rochester. NY 35 was split into two routes in the early 1940s, at which time NY 383 was assigned to the portion between Mumford and Walworth. NY 383 was truncated to Rochester in 1949, and only minor realignments within the city have occurred since.