New York State Route 146

New York State Route 146 (NY 146) is a state highway in the Capital District of New York in the United States. It extends for 43 miles (69 km) from Gallupville at NY 443 to near Mechanicville at U.S. Route 4 (US 4) and NY 32. NY 146 is a major thoroughfare in the city of Schenectady, just outside of Albany. Most of the route follows an east–west alignment; however, the middle third of the route between Guilderland and Clifton Park runs in a more north–south manner in order to serve Schenectady. At one time, NY 146 had three spur routes; only one—NY 146A—still exists.

NY 146 was assigned as part of the 1930 renumbering of state highways in New York. At the time, NY 146 began at modern NY 443 in Berne and followed what is now NY 156 northeast to Altamont while modern NY 146 west of Altamont was part of NY 156. The alignments of the two routes were flipped in the late 1930s. Other minor realignments have occurred since, most notably near Mechanicville.