Neutrophil Cytosolic Factor 2

Identifiers Symbols NCF2; NCF-2; NOXA2; P67-PHOX; P67PHOX External IDs OMIM: 608515 MGI: 97284 HomoloGene: 374 GeneCards: NCF2 Gene

Gene Ontology
Molecular function protein binding
protein C-terminus binding
electron carrier activity
Rac GTPase binding
Cellular component acrosomal vesicle
nucleolus
cytoplasm
cytosol
phagolysosome
NADPH oxidase complex
Biological process antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
superoxide metabolic process
cellular defense response
aging
response to glucose stimulus
response to activity
response to lipopolysaccharide
response to progesterone stimulus
cellular response to hormone stimulus
response to laminar fluid shear stress
response to drug
superoxide anion generation
antigen processing and presentation of exogenous peptide antigen via MHC class I
positive regulation of neuron apoptotic process
innate immune response
respiratory burst
positive regulation of blood pressure
interaction with host
response to hyperoxia
phagosome maturation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4688 17970 Ensembl ENSG00000116701 ENSMUSG00000026480 UniProt P19878 O70145 RefSeq (mRNA) NM_000433 NM_010877 RefSeq (protein) NP_000424 NP_035007 Location (UCSC) Chr 1:
183.52 – 183.56 Mb Chr 1:
152.81 – 152.84 Mb PubMed search

Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.

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