Function
The activation of NmU receptors leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling, and the inhibition of cAMP production
NmU will contract smooth muscle only in a tissue- and species-specific manner. Intracerebroventricular (or i.c.v) administration of the neuropeptide mediates stress response and increases both the arterial pressure and heart rate. i.c.v administration of NmU elevates the plamsa adrenaline levels, though has no effect on the amount of plasma noradrenaline. It has been suggested that large doses of NmU inhibits the activity of the paraventricular nucleus of hypothalamus and/or the sympathetic preganglionic neurons, thus controlling the activity.
Read more about this topic: Neuromedin U
Famous quotes containing the word function:
“The art of living is to function in society without doing violence to one’s own needs or to the needs of others. The art of mothering is to teach the art of living to children.”
—Elaine Heffner (20th century)
“For me being a poet is a job rather than an activity. I feel I have a function in society, neither more nor less meaningful than any other simple job. I feel it is part of my work to make poetry more accessible to people who have had their rights withdrawn from them.”
—Jeni Couzyn (b. 1942)
“Morality and its victim, the mother—what a terrible picture! Is there indeed anything more terrible, more criminal, than our glorified sacred function of motherhood?”
—Emma Goldman (1869–1940)