Group Structure
Risch has worked on the genetic structure of human groups, for instance multiple levels of structure above the level of the individual increasing in scale up to the level of race. He has translated these results into theoretical impacts on, for instance, rate of decay of linkage disequilibrium, and practical application in personalised medicine. For instance, using the Framingham data, he showed that population stratification leads not only to a fewer heterozygotes than predicted from Hardy-Weinberg Equilibrium but also to spouses sharing identical genotypes at all ancestrally informative markers, accounted for by ancestry-related assortative mating in the previous generation.
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