Neighbouring group participation (NGP) or Anchimeric assistance in organic chemistry has been defined by IUPAC as the interaction of a reaction centre with a lone pair of electrons in an atom or the electrons present in a sigma bond or pi bond . When NGP is in operation it is normal for the reaction rate to be increased. It is also possible for the stereochemistry of the reaction to be abnormal (or unexpected) when compared with a normal reaction. While it is possible for neighbouring groups to influence many reactions in organic chemistry (For instance the reaction of a diene such as cyclohex-1,3-diene with maleic anhydride normally gives the endo isomer because of a secondary effect {overlap of the carbonyl group π orbitals with the transition state in the Diels-Alder reaction}) this page is limited to neighbouring group effects seen with carbocations and SN2 reactions.
Read more about Neighbouring Group Participation: NGP By Heteroatom Lone Pairs, NGP By An Alkene, NGP By A Cyclopropane, Cyclobutane or A Homoallyl Group, NGP By An Aromatic Ring, External Links
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