Pathogenesis
Until recently, necrosis was thought to be an unregulated process . There are two broad pathways in which necrosis may occur in an organism.
The first of these two pathways initially involves oncosis, where swelling of the cells occur. The cell then proceeds to blebbing, and this is followed by pyknosis, in which nuclear shrinkage transpires. In the final step of this pathway the nucleus is dissolved into the cytoplasm, which is referred to as karyorrhexis.
The second pathway is a secondary form of necrosis that is shown to occur after apoptosis and budding. Cellular changes of necrosis occur in this secondary form of apoptosis, where the nucleus breaks into fragments, which is known as karyolysis.
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