NDS is an initialism may stand for:
- Low German (Dutch: Nedersaksisch, German: Niederdeutsche Sprache, ISO 639-2 language code: NDS), a regional language spoken in the north of Germany and the northeast of the Netherlands
- Lower Saxony (German: Niedersachsen)
- NDS Group, a company specializing in television technology, including digital rights management
- NDS is also used as shorthand for Videoguard, the encryption system created by NDS Group
- National Directorate of Security (Afghanistan), an Afghan government agency
- Nintendo DS, a portable game system by Nintendo
- Novell eDirectory, formerly Novell Directory Services, directory service software for a network
- Nuclear Detection System, a system to detect the blast of a nuclear device
- New Data Seal, an encryption algorithm
- News Distribution Service, operated by the UK government's Central Office of Information
- NDS, Inc, a producer of plastic drainage products
- Non-drive side, a cycling term for the left side of a bicycle
- Nouvelle Démocratie Sociale
- Navigation Data Standard
- Short for Network Data Systems, an IT professional services firm
- Bosnian: Nova Demokratska Stranka Nova Demokratska Stranka a Bosniak Party in the municipality of Prizren.
- Nickname for Nick Dal Santo, Australian Rules footballer
- NASA Docking System, a spacecraft docking and berthing mechanism being developed by NASA for the next generation of space exploration vehicles.