In enzymology, a myosin-heavy-chain kinase (EC 2.7.11.7) is an enzyme that catalyzes the chemical reaction
- ATP + ADP + phosphate
Thus, the two substrates of this enzyme are ATP and myosin heavy-chain, whereas its two products are ADP and myosin heavy-chain phosphate.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP: O-phosphotransferase. Other names in common use include
- ATP:myosin-heavy-chain O-phosphotransferase
- calmodulin-dependent myosin heavy chain kinase
- MHCK
- MIHC kinase
- myosin heavy chain kinase
- myosin I heavy-chain kinase
- myosin II heavy-chain kinase
- kinase
- myosin heavy chain kinase A
- STK6.