Myosatellite Cell - Effects of Exercise On Satellite Cell Activity

Effects of Exercise On Satellite Cell Activity

Satellite cell activation is measured by the extent of proliferation and differentiation. Typically, satellite cell content is expressed per muscle fiber or as a percentage of total nuclear content, the sum of satellite cell nuclei and myonuclei. While the adaptive response to exercise largely varies on an individual basis on factors such as genetics, age, diet, acclimatization to exercise, and exercise volume, human studies have demonstrated general trends.

It is suggested that exercise triggers the release of signaling molecules including inflammatory substances, cytokines and growth factors from surrounding connective tissues and active skeletal muscles. Notably, HGF, a cytokine, is transferred from the extracellular matrix into muscles through the nitric-oxide dependent pathway. It is thought that HGF activates satellite cells, while insulin growth factor-I (IGF-1) and fibroblast growth factor (FGF) enhance satellite cell proliferation rate following activation. Studies have demonstrated that intense exercise generally increases IGF-1 production, though individual responses vary significantly. More specifically, IGF-1 exists in two isoforms: mechano growth factor (MGF) and IGF-IEa. While the former induces activation and proliferation, the latter causes differentiation of proliferating satellite cells.

Human studies have shown that both high resistance training and endurance training have yielded an increased number of satellite cells. These results suggest that a light, endurance training regimen may be useful to counteract the age-correlated satellite cell decrease. In high-resistance training, activation and proliferation of satellite cells are evidenced by increased cyclinD1 mRNA, and p21 mRNA levels. This is consistent with the fact that cyclinD1 and p21 upregulation correlates to division and differentiation of cells.

Satellite cell activation has also been demonstrated on an ultrastructural level following exercise. Aerobic exercise has been shown to significantly increase granular endoplasmic reticulum, free ribosomes, and mitochondria of the stimulated muscle groups. Additionally, satellite cells have been shown to fuse with muscle fibers, developing new muscle fibers. Other ultrastructural evidence for activated satellite cells include increased concentration of Golgi apparatus and pinocytotic vesicles.

Read more about this topic:  Myosatellite Cell

Famous quotes containing the words effects of, effects, exercise, satellite, cell and/or activity:

    Some of the greatest and most lasting effects of genuine oratory have gone forth from secluded lecture desks into the hearts of quiet groups of students.
    Woodrow Wilson (1856–1924)

    Consider what effects which might conceivably have practical bearings we conceive the object of our conception to have. Then our conception of these effects is the whole of our conception of the object.
    Charles Sanders Peirce (1839–1914)

    The division between the useful arts and the fine arts must not be understood in too absolute a manner. In the humblest work of the craftsmen, if art is there, there is a concern for beauty, through a kind of indirect repercussion that the requirements of the creativity of the spirit exercise upon the production of an object to serve human needs.
    Jacques Maritain (1882–1973)

    Books are the best things, well used; abused, among the worst. What is the right use? What is the one end, which all means go to effect? They are for nothing but to inspire. I had better never see a book, than to be warped by its attraction clean out of my own orbit, and made a satellite instead of a system.
    Ralph Waldo Emerson (1803–1882)

    each in the cell of himself is almost convinced of his freedom,
    —W.H. (Wystan Hugh)

    Labor is work that leaves no trace behind it when it is finished, or if it does, as in the case of the tilled field, this product of human activity requires still more labor, incessant, tireless labor, to maintain its identity as a “work” of man.
    Mary McCarthy (1912–1989)