Cancer Research
Except for early response genes, Myc universally upregulates gene expression. Furthermore the upregulation is nonlinear. Genes whose expression is already signficicantly upregulated in the absence of Myc are strongly boosted in the presence of Myc where as genes whose expression is low in the absence Myc only get a small boost when Myc is present.
Inactivation of SUMO-activating enzyme (SAE1 / SAE2) in the presence of Myc hyperactivation results in mitotic catastrophe and cell death in cancer cells. Hence inhibitors of SUMOylation may be a possible treatment for cancer.
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