Cast
- Dane Cook as Sherman 'Tank' Turner, a help line operator with a hobby of taking girls on horrible dates.
- Kate Hudson as Alexis, Dustin's co-worker and Tank's love interest.
- Jason Biggs as Dustin, Tank's best friend and roommate.
- Diora Baird as Rachel, Alexis's sister and one of Tank's bad dates.
- Alec Baldwin as Professor William Turner, Tank's father.
- Lizzy Caplan as Ami, Alexis's best friend and roommate.
- Taran Killam as Josh, Rachel's groom.
- Malcolm Barrett as Dwalu, Tank's friend and colleague from the call center.
- Riki Lindhome as Hilary, a deeply Christian girl.
- Mini Anden as Lizzy, one of Tank's one-night-stands.
- Robert Fennessy II as the Bartender
- Brad Garret uncredited cameo as angry customer on phone.
Read more about this topic: My Best Friend's Girl (2008 Film)
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