Musto is an Italian and English surname and can refer to:
- Sir Arnold Musto, born 1883, British Civil Engineer who designed the Sukkur Barrage.
- Michael Musto, Italian-American writer
- Glenn Musto, singer-songwriter of pop band College Fall
- Tony Musto (1915 - 1994), an Italian-American heavyweight boxer
- Ray Musto, a politician from Pennsylvania
- Alissa Musto, American singer and pianist
- Billy Musto, a politician from New Jersey
- Manuel Musto, an Argentinian impressionist painter
- Biagio Musto, bishop of Sora-Aquino-Pontecorvo (1952 - 1971)
- Franklyn Musto, an English athlete at the 1964 Olympics.
- Keith Musto, a British sailor at the 1964 Olympics.
- Adam Musto, an American journalist.
- Adrian Musto, an Italian documentary filmmaker.
In addition, it can refer to:
- Musto, an outdoor clothing company headquartered in England
- Musto Performance Skiff, a single-handed sailing skiff
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