Muskogee or Muscogee can refer to:
- Muscogee people, indigenous peoples of the southeastern woodlands
- Muscogee (Creek) Nation, a federally recognized Muscogee tribe in Oklahoma
- Muskogean languages, including the Muscogee language
- Muscogee, Florida, a ghost town
- Muskogee, Oklahoma, USA, a city
- Muscogee County, Georgia
- Muskogee County, Oklahoma
- State of Muskogee, a short-lived nation