Muscarinic Acetylcholine Receptor M3
| Gene Ontology | |
|---|---|
| Molecular function | • phosphatidylinositol phospholipase C activity • receptor activity • drug binding • G-protein coupled acetylcholine receptor activity • acetylcholine binding |
| Cellular component | • plasma membrane • integral to plasma membrane • basolateral plasma membrane • cell junction • dendrite • asymmetric synapse • axon terminus • postsynaptic membrane |
| Biological process | • regulation of vascular smooth muscle contraction • energy reserve metabolic process • cellular protein modification process • smooth muscle contraction • signal transduction • G-protein coupled receptor signaling pathway • nervous system development • digestion • cell proliferation • small molecule metabolic process • positive regulation of smooth muscle contraction • regulation of insulin secretion |
| Sources: Amigo / QuickGO | |
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The muscarinic acetylcholine receptor M3, also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor. It is encoded by the human gene CHRM3.
The M3 muscarinic receptors are located at many places in the body, e.g., smooth muscles, the endocrine glands, the exocrine glands,lungs, pancreas and the brain. In the CNS, they induce emesis. Muscarinic M3 receptors are expressed in regions of the brain that regulate insulin homeostasis, such as the hypothalamus and dorsal vagal complex of the brainstem. These receptors are highly expressed on pancreatic beta cells and are critical regulators of glucose homoestasis by modulating insulin secretion. In general, they cause smooth muscle contraction and increased glandular secretions.
They are unresponsive to PTX and CTX.
Read more about Muscarinic Acetylcholine Receptor M3: Mechanism, Agonists, Antagonists, Interactions
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