Genotypes
Although there is only one serotype of mumps virus, according to recent update by WHO (June 2012), There are currently 12 genotypes A-N, (namely A, B, C, D, F, G, H, I, J, K, L, N) excluding (E and M)and L-Zagreb vaccine strain comes under genotype N. The typing scheme is based on the sequence of the small hydrophobic (SH) gene. There have been no reports on the prevalence of mumps infection or its genotype of MuVs in India. First report of identification genotype C circulating MuVs in India especially at Chennai by Jeevan Malayan and Elanchezhiyan M (Department of Microbiology, Dr. ALM PG IBMS, University of Madras, Chennai, India. It has been named as MuVi/Chennai.IND/29.12 and sequences are submitted to GenBank (accession number: JX392385, JX392386, JX456273, JX456274).
There are several subgenotypes ((D1, D2 G1, G2, H1, H2) which are designated by numerals after the letter.
Among vaccine strains Jerryl Lynn and Rubini belong to genotype A, Urabe is genotype B. It is not clear yet if there is any clinical significance to the genotypes.
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