Multiple EM For Motif Elicitation - Algorithm Components

Algorithm Components

The algorithm uses several types of well known functions:

  • Expectation maximization (EM).
  • EM based heuristic for choosing the EM starting point.
  • Maximum likelihood ratio based (LRT-based). Heuristic for determining the best number of model-free parameters.
  • Multi-start for searching over possible motif widths.
  • Greedy search for finding multiple motifs.

However, one often doesn't know where the starting position is. Several possibilities exist:

  • Exactly one motif per sequence.
  • One or zero motif per sequence.
  • Any number of motifs per sequence.

Read more about this topic:  Multiple EM For Motif Elicitation

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