Mudd is a surname, and may refer to:
- Daniel Mudd (b. 1956), American CEO, son of Roger Mudd
- Harvey Seeley Mudd (1888-1955), American mining engineer, namesake of Harvey Mudd College
- Howard Mudd (b. 1942), American football player and coach
- Richard Mudd (1901-2002), grandson of Samuel Mudd
- Roger Mudd (b. 1928), U.S. television journalist
- Samuel Mudd (1833-1883), physician who set John Wilkes Booth's broken leg
- Seeley G. Mudd (1895-1968), California physician whose foundation allowed for the construction of several academic halls in U.S. colleges and universities
- Seeley W. Mudd (1861-1926), American mining engineer, father of Harvey Seeley Mudd and Seeley G. Mudd
Fictional characters
- Harry Mudd, who appears in Star Trek: The Original Series and Star Trek: The Animated Series
- Lt. Mudd, a character in Joseph Heller's novel Catch-22
- Millicent Mudd