Computing and Networking
- Managed Service Point, such as a Demarcation point or equipment room/location
- Managed service provider, a business model for providing information-technology services
- Message send protocol, an application-layer computing protocol used to send a short message between networking nodes on a computer network
- Message Submission Program or smmsp in Sendmail e-mail systems
- Microsoft Installer Patch Files, files downloaded from updating applications installed with Microsoft Installer and which have the .msp file extension
- Microsoft Points, the currency used on the Xbox Live and Zune marketplaces
- Microsoft Project, a project-management software program developed and sold by Microsoft
- Microsoft Student Partners, an organization of university students interested in careers in technology and showing a willingness to help others learn about Microsoft technology
- MSP and MSP/EX, Fujitsu operating systems
- MSP (file format), a pre-bmp picture format readable in the oldest versions of Microsoft Paint
- Multiplex Section Protection, an Asynchronous Transfer Mode (ATM) link-protection 1+1 fail-over mechanism
- Mobility Services Platform, a server based software to manage Symbol/Motorola mobile computers
- Max/MSP, max signal processing
- Mixed-signal processor, see mixed-signal integrated circuit
- TI MSP430
- MSPS, Mega Samples Per Second
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