MSF may refer to:
- Mail Summary File (.msf), file extension used by Earthlink, Mozilla Thunderbird, and Netscape mail clients to store folder data in Mork.
- Marvel Super Heroes vs. Street Fighter, a fighting game by Capcom featuring Marvel Comics and Street Fighter characters
- Frankenstein (1994 film), also known as Mary Shelley's Frankenstein
- Master of Science in Finance
- Metasploit Framework an open-source computer security project which provides information about security vulnerabilities and aids in penetration testing and IDS signature development
- Microsoft SharePoint Foundation, formerly known as Windows SharePoint Services
- Microsoft Solutions Framework
- Military science fiction
- Multi-Stage Flash, a water desalination process
- Municipal solid waste, garbage
- Time from NPL, UK National Physical Laboratory time signal (which historically used the MSF radio call sign)
Read more about MSF: Organizations