Work
Sur is a pioneer in the study of brain plasticity and its mechanisms. Using experimental and theoretical approaches, his laboratory studies developmental plasticity and the dynamic changes in mature cortical networks during information processing, learning and memory. His laboratory has discovered fundamental principles by which neurons of the cerebral cortex are wired during development and change dynamically in adulthood. In landmark experiments, he “rewired” the brain to explore how the environment influences the development of cortical circuits. The retina, which normally projects to the visual cortex, was induced to project to structures that normally process hearing. Visual input altered the development of neuronal connections in the auditory cortex, thus enabling animals to use their "hearing" cortex to "see."
These findings have implications for restoring function after brain damage and for constructing neural prostheses for recovery from stroke or trauma. The Sur laboratory also studies genes involved in constructing the cerebral cortex, and the ways in which gene networks are influenced by brain activity. These studies are providing important insights into childhood disorders such as autism. Stemming from this work, a pharmacological treatment for Rett Syndrome has entered clinical trials.
By imaging calcium responses of single neurons and astrocytes in vivo using high resolution imaging methods, his laboratory has discovered that astrocytes have remarkably specific functional properties and mediate blood flow to active brain regions. This work has revealed the mechanism for noninvasive brain imaging methods such as functional magnetic resonance imaging (fMRI).
The Sur laboratory has also shown how neurons of the mature visual cortex alter their responses dynamically based on the configuration of visual stimuli in space and time. The laboratory studies the mechanisms by which visual neurons at the earliest stages of cortical processing are influenced not only by “bottom up” visual inputs but also in “top down” manner by mental state, including attention and expectation. These studies provide fundamental information about higher brain mechanisms, including those involved in vision, cognition, and learning.
Read more about this topic: Mriganka Sur
Famous quotes containing the word work:
“Neither a work of nature nor one of art we get to know when they have been finished; we must surprise them in the process of being created so as to understand them to some degree.”
—Johann Wolfgang Von Goethe (1749–1832)
“The most striking fault in work by young or beginning novelists, submitted for criticism, is irrelevance—due either to infatuation or indecision. To direct such an author’s attention to the imperative of relevance is certainly the most useful—and possibly the only—help that can be given.”
—Elizabeth Bowen (1899–1973)
“You haf slafed your life away in de bosses’ mills and your fadhers before you and your kids after you yet. Vat is a man to do with seventeen-fifty a week? His wife must work nights to make another ten, must vork nights and cook and wash in day an’ vatfor? So that the bosses can get rich an’ the stockholders and bondholders. It is too much... ve stood it before because ve vere not organized. Now we have union... We must all stand together for union.”
—John Dos Passos (1896–1970)