The MMTV Promoter in Models of Human Breast Cancer
The LTR (long terminal repeat) of MMTV contains a glucocorticoid hormone response element. This glucocorticoid element is a promoter that is often used to construct mice which develop a breast cancer-like disease, because an animal model system for breast cancer close to the human disease is very much looked for.
The MMTV promoter is used in the PyMT model system of breast cancer. Here Py is the abbreviation of polyoma and MT is the abbreviation for middle T. There are more model systems of breast cancer which use the MMTV promoter. The polyoma middle T-antigen is taken from the polyoma virus. In human breast cancer the polyoma middle T- antigen was not found.
Read more about this topic: Mouse Mammary Tumor Virus
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