Mouse Mammary Tumor Virus - The MMTV Promoter in Models of Human Breast Cancer

The MMTV Promoter in Models of Human Breast Cancer

The LTR (long terminal repeat) of MMTV contains a glucocorticoid hormone response element. This glucocorticoid element is a promoter that is often used to construct mice which develop a breast cancer-like disease, because an animal model system for breast cancer close to the human disease is very much looked for.

The MMTV promoter is used in the PyMT model system of breast cancer. Here Py is the abbreviation of polyoma and MT is the abbreviation for middle T. There are more model systems of breast cancer which use the MMTV promoter. The polyoma middle T-antigen is taken from the polyoma virus. In human breast cancer the polyoma middle T- antigen was not found.

Read more about this topic:  Mouse Mammary Tumor Virus

Famous quotes containing the words promoter, models, human, breast and/or cancer:

    What every artist should try to prevent is the car, in which is our civilized life, plunging over the side of the precipice—the exhibitionist extremist promoter driving the whole bag of tricks into a nihilistic nothingness or zero.
    Wyndham Lewis (1882–1957)

    ... your problem is your role models were models.
    Jane Wagner (b. 1935)

    The only human beings I have thoroughly admired and respected in the world have been those who carried the load of the world with a smile, and who, in the face of anxieties that would have knocked me clean out, never showed a tremor. Such men and women end by owning us, soul and body, and our allegiance can never be shaken. We are only too glad to be owned. Religion is nothing but this.
    Henry Brooks Adams (1838–1918)

    He bore her away in his arms,
    The handsomest young man there,
    And his neck and his breast and his arms
    Were drowned in her long dim hair.
    William Butler Yeats (1865–1939)

    We “need” cancer because, by the very fact of its incurability, it makes all other diseases, however virulent, not cancer.
    Gilbert Adair, British author, critic. “Under the Sign of Cancer,” Myths and Memories (1986)