Motor Unit Recruitment - Neuronal Mechanism of Recruitment

Neuronal Mechanism of Recruitment

Henneman proposed that the mechanism underlying the Size Principle was that the smaller motor neurons had a smaller surface area and therefore a higher membrane resistance. He predicted that the current generated by an excitatory postsynaptic potential (EPSPs) would result in a higher voltage change (depolarization) across the neuronal membrane of the smaller motor neurons and therefore larger EPSPs in smaller motoneurons. Burke later demonstrated that there was a graded decrease of both EPSP inhibitory post synaptic potential (IPSP) amplitudes from small to large motoneurons. This seemed to confirm Henneman's idea, but Burke disagreed, pointing out that larger neurons with a larger surface area had space for more synapses. Burke eventually showed (in a very small sample of neurons) that smaller motoneurons have a greater number of synaptic inputs from a single input source. The topic is probably still regarded as controversial.

Under some circumstances, the normal order of motor unit recruitment may be altered, such that small motor units cease to fire and larger ones may be recruited. This is thought to be due to the interaction of excitatory and inhibitory motoneuronal inputs.