Mosconi may refer to:
- Judah Leon ben Moses Mosconi (1328–unknown), a Bulgarian scholar and Talmudist
- Enrique Mosconi (1877–1940), Argentine military engineer.
- Willie Mosconi (1913–1993), American professional pool player from Philadelphia, Pennsylvania
- Mosconi Cup, an annual nine-ball pool tournament contested between teams representing Europe and the United States since 1994, named in honor of Willie Mosconi
- Germano Mosconi (born 1932), sports journalist and television anchorman
- Alain Mosconi (born 1949), French swimmer, Olympic medalist and previous world record holder.