Examples
For a more comprehensive list, see List of monoclonal antibodies. List of FDA approved therapeutic antibodies is found in Monoclonal antibody therapyBelow are examples of clinically important monoclonal antibodies.
| Main category | Type | Application | Mechanism/Target | Mode |
|---|---|---|---|---|
| Anti- inflammatory |
infliximab |
|
inhibits TNF-α | chimeric |
| adalimumab |
|
inhibits TNF-α | human | |
| basiliximab |
|
inhibits IL-2 on activated T cells | chimeric | |
| daclizumab |
|
inhibits IL-2 on activated T cells | humanized | |
| omalizumab |
|
inhibits human immunoglobulin E (IgE) | humanized | |
| Anti-cancer | gemtuzumab |
|
targets myeloid cell surface antigen CD33 on leukemia cells | humanized |
| alemtuzumab |
|
targets an antigen CD52 on T- and B-lymphocytes | humanized | |
| rituximab |
|
targets phosphoprotein CD20 on B lymphocytes | chimeric | |
| trastuzumab |
|
targets the HER2/neu (erbB2) receptor | humanized | |
| nimotuzumab |
|
EGFR inhibitor | Humanized | |
| cetuximab |
|
EGFR inhibitor | Chimeric | |
| bevacizumab |
|
inhibits VEGF | humanized | |
| Other | palivizumab |
|
inhibits an RSV fusion (F) protein | humanized |
| abciximab |
|
inhibits the receptor GpIIb/IIIa on platelets | chimeric |
Read more about this topic: Monoclonal Antibodies
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“No rules exist, and examples are simply life-savers answering the appeals of rules making vain attempts to exist.”
—André Breton (1896–1966)
“Histories are more full of examples of the fidelity of dogs than of friends.”
—Alexander Pope (1688–1744)
“There are many examples of women that have excelled in learning, and even in war, but this is no reason we should bring ‘em all up to Latin and Greek or else military discipline, instead of needle-work and housewifry.”
—Bernard Mandeville (1670–1733)