Fictional Characters
- Mona Stevens, in Landfall by Nevil Shute
- Mona from the WarioWare series
- Mona, Ross Geller's girlfriend in the television series Friends, played by Bonnie Somerville
- Mona Mayfair in several novels by Anne Rice
- Mona McCluskey, central character in television sitcom of the same name
- Mona Parker, central character in the animated television series Mona the Vampire
- Mona Ramsey, a major female character from the Tales of the City books by Armistead Maupin Portrayed first by Chloe Webb and then by Nina Siemaszko.
- Mona Sax, the lead female character in the Max Payne video game series, portrayed by Mila Kunis in the 2008 film.
- Mona Simpson in The Simpsons; Homer Simpson's estranged mother.
- Mona Vanderwaal in Pretty Little Liars
- In Mona Lisa Overdrive, the final novel of William Gibson's Sprawl trilogy, Mona is a young prostitute
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