Methods of Introduction
Water solubilizing groups are best introduced at the beginning of a drug synthesis, although they may be introduced at any stage. Introduction at the beginning avoids the problem of a later introduction changing the type and/or nature of the drug–receptor interaction. A wide variety of routes may be used to introduce a water solubilizing group; the one selected will depend on the type of group being introduced and the chemical nature of the target structure. Many of these routes require the use of protecting agents to prevent unwanted reactions of either the water solubilizing group or the lead structure.
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